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* '''Day 4:''' simultaneously start administration of bupropion in a dosage of 150 mg/day and continue administration of doxepin according to the scheme above.
* '''Day 8:''' stop administration of doxepin and continue administration of bupropion.
* '''Day 15:''' if necessary increase bupropion.
| info =
* Bupropion is a strong inhibitor of CYP2D6, which metabolizes doxepin.
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