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| to = amitriptyline
| stop =
* '''Before day 1:''' Gradually reduce dosage of bupropion to a maximum of 150 mg/ day. * When a dosage '''Day 1:''' Stop administration of 150 mg/day is reached, stop administration.bupropion
| start =
* '''Day 1-3:''' start administration of amitriptyline the next day in a low dosage of 25 mg/day.
* '''Day 4:''' increase dosage of amitriptyline to 50 mg/day and continue slowly increasing the dosage depending on the condition of the patient.
| info =
* Bupropion slows the metabolism of amitriptyline via CYP2D6.
* Caution is necessary at the start of administration of amitriptyline. }}