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Caution is necessary for at least four weeks.
* '''Day 1:''' start administration of doxepin in a low dosage of 25 mg/day.
* '''Day 1514:''' increase dosage of doxepin to 50 mg/day.
* '''Day 28:''' increase dosage of doxepin to 75 mg/day.
| info =
* Fluoxetine slows and norfluoxetine slow the metabolism of doxepin via CYP2D6. * Desmethylfluoxetine Norfluoxetine has a halflife of at least 1 week: it takes therefore 1 month for elemination.
* Start low, go slow for doxepin.}}