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| start =
* '''Day 8-14:''' a wash-out period of one week is necessary.
* '''Day 15:''' start administration of duloxetine in a normal dosage of 60 mg/day. | info = * Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.* Duloxetine is an inhibitor of CYP2D6, which metabolizes amitriptyline. }}