| base = Lithiumlithium| add = Risperidonerisperidone
| info =
* Lithium is eliminated by the kidney for about 95%. Changes in the rate of excretion can cause unwanted effects.* Risperidone is principally metabolized by CYP2D6 to an active metabolite.* This combination of drugs may have possible synergistic effects. However, this combination will also have additive side effects<ref name="freeman">{{Pubmed|9433333|Freeman et al. Mood stabilizer Combinations: A Review of Safety and Efficacy. Dose adaptation will be recommended for this combinationAm J Psychiatry 1998;155:12-21}}</ref>.
| start =
* Start risperidone according to the general dosing advice.
| cave =
* The concomitant administration of lithium with neuroleptic agents may increase the risk of extrapyramidal reactions and neurotoxicity.