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* '''Day 1:''' reduce dosage of imipramine to 50 mg/day.
* '''Day 3:''' reduce dosage of imipramine to 25 mg/day.
* '''Day 8:''' stop administration of imipramine.
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* '''Day 1:''' simultaneously start administration of citalopram/escitalopram in a normal dosage of 20 mg/day, resp. 10 mg/day.* '''Day 8:''' stop administration of imipramine and continue administration of citalopram/escitalopram.
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* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
* Citalopram/escitalopram are is a weak inhibitor of CYP2D6, which metabolizes imipramine.
* {{theorSS}}
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