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Created page with '{{Drugcombi | base = valproic acid | add = lithium | info = * Valproic acid is principally metabolized by CYP2C9, CYP2C19, CYP2A6 and UDP-glucuronosyltransferases. Valproic acid...'
{{Drugcombi
| base = valproic acid
| add = lithium
| info =
* Valproic acid is principally metabolized by CYP2C9, CYP2C19, CYP2A6 and UDP-glucuronosyltransferases. Valproic acid is an inhibitor of the enzymes CYP2C9, epoxide-hydroxylase and UDP-glucuronosyltransferases.
* Lithium is eliminated by the kidney for about 95%. Changes in the rate of excretion can cause unwanted effects.
* This combination of drugs may have possible synergistic effects. However, this combination will also have additive side effects. Dose adaptation will be recommended for this combination.
| start =
* Start valproic acid according to the general dosing advice.
| cave =
}}
| base = valproic acid
| add = lithium
| info =
* Valproic acid is principally metabolized by CYP2C9, CYP2C19, CYP2A6 and UDP-glucuronosyltransferases. Valproic acid is an inhibitor of the enzymes CYP2C9, epoxide-hydroxylase and UDP-glucuronosyltransferases.
* Lithium is eliminated by the kidney for about 95%. Changes in the rate of excretion can cause unwanted effects.
* This combination of drugs may have possible synergistic effects. However, this combination will also have additive side effects. Dose adaptation will be recommended for this combination.
| start =
* Start valproic acid according to the general dosing advice.
| cave =
}}