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Created page with '{{Drugcombi | base = risperidone | add = lamotrigine | info = * Risperidone is principally metabolized by CYP2D6 to an active metabolite. * Lamoptrigine is principally metabolis...'
{{Drugcombi
| base = risperidone
| add = lamotrigine
| info =
* Risperidone is principally metabolized by CYP2D6 to an active metabolite.
* Lamoptrigine is principally metabolised by UDP-glucuronosyltransferases.
* This combination of drugs may have possible synergistic effects. However, this combination will also have additive side effects. Dose adaptation will be recommended for this combination.
| start =
* Start lamotrigine according to the general dosing advice.
| cave =
* A case report suggests that lamotrigine may increase the plasma concentrations of risperidone. <ref> {{Pubmed|15800164|Bienentreu at al, Increase in risperidone plasma level with lamotrigine. Am J Psychiatry. 2005 Apr;162(4):811-2}}</ref>
* Pharmacologic response and serum risperidone levels should be monitored more closely whenever lamotrigine is added to or withdrawn from therapy. <ref name="drugscom">
{{Drugscominteract|risperidone-with-lamotrigine-1744-0-2286-0|risperidone|lamotrigine}}</ref>
}}
Pharmacologic response and serum risperidone levels should be monitored more closely whenever lamotrigine is added to or withdrawn from therapy, and the risperidone dosage adjusted as necessary.
| base = risperidone
| add = lamotrigine
| info =
* Risperidone is principally metabolized by CYP2D6 to an active metabolite.
* Lamoptrigine is principally metabolised by UDP-glucuronosyltransferases.
* This combination of drugs may have possible synergistic effects. However, this combination will also have additive side effects. Dose adaptation will be recommended for this combination.
| start =
* Start lamotrigine according to the general dosing advice.
| cave =
* A case report suggests that lamotrigine may increase the plasma concentrations of risperidone. <ref> {{Pubmed|15800164|Bienentreu at al, Increase in risperidone plasma level with lamotrigine. Am J Psychiatry. 2005 Apr;162(4):811-2}}</ref>
* Pharmacologic response and serum risperidone levels should be monitored more closely whenever lamotrigine is added to or withdrawn from therapy. <ref name="drugscom">
{{Drugscominteract|risperidone-with-lamotrigine-1744-0-2286-0|risperidone|lamotrigine}}</ref>
}}
Pharmacologic response and serum risperidone levels should be monitored more closely whenever lamotrigine is added to or withdrawn from therapy, and the risperidone dosage adjusted as necessary.