387
edits
Changes
Created page with '{{Drugcombi | base = quetiapine | add = carbamazepine | info = * Quetiapine is principally metabolized by CYP3A4 to active and inactive metabolites. * Carbamazepine is principa...'
{{Drugcombi
| base = quetiapine
| add = carbamazepine
| info =
* Quetiapine is principally metabolized by CYP3A4 to active and inactive metabolites.
* Carbamazepine is principally metabolized by CYP3A4 (also CYP2C8), but is also a potent inducer of CYP1A2, CYP3A4 and UDP-glucuronosyltransferases.
* This combination of drugs may have possible synergistic effects. However, this combination will also have additive side effects. Dose adaptation will be recommended for this combination.
| start =
* Start carbamazepine according to the general dosing advice.
* The pharmacologic response to quetiapine should be monitored more closely. Dose adoptation of quetiapine could be necessary.
| cave =
* Carbamazepine can reduce quetiapine serum concentration, possible below therapeutic range. <ref> {{Pubmed|15385830|Hasselstrom and Linnet, Quetiapine serum concentrations in psychiatric patients: the influence of comedication. Ther Drug Monit 2004;26:486-91}}</ref>
}}
| base = quetiapine
| add = carbamazepine
| info =
* Quetiapine is principally metabolized by CYP3A4 to active and inactive metabolites.
* Carbamazepine is principally metabolized by CYP3A4 (also CYP2C8), but is also a potent inducer of CYP1A2, CYP3A4 and UDP-glucuronosyltransferases.
* This combination of drugs may have possible synergistic effects. However, this combination will also have additive side effects. Dose adaptation will be recommended for this combination.
| start =
* Start carbamazepine according to the general dosing advice.
* The pharmacologic response to quetiapine should be monitored more closely. Dose adoptation of quetiapine could be necessary.
| cave =
* Carbamazepine can reduce quetiapine serum concentration, possible below therapeutic range. <ref> {{Pubmed|15385830|Hasselstrom and Linnet, Quetiapine serum concentrations in psychiatric patients: the influence of comedication. Ther Drug Monit 2004;26:486-91}}</ref>
}}