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* '''Day 1:''' reduce dosage of fluvoxamine to a maximum of 25 mg/day.
| start =
* '''Day 1:''' simultaneously start administration of doxepin in a low dosage of 25 mg/day.
* '''Day 8:''' stop administration of fluvoxamine and continue administration of doxepin only. If necessary, increase dosage of doxepin.
| info =
* Fluvoxamine slows the metabolism is an inhibitor of doxepin via CYP2D6CYP1A2, CYP2C19 and possibly via CYP1A2 tooCYP3A4 (moderate), which metabolize doxepin.
* "Start low, go slow" is not required, but caution is necessary.}}