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* '''Day 1:''' reduce dosage of fluvoxamine to a maximum of 25 mg/day.
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* '''Day 1:''' simultaneously start administration of imipramine in a low dosage of 25 mg/day.
* '''Day 8:''' stop administration of fluvoxamine and continue administration of imipramine in a dosage of 50 mg/day.
* Start low, go slow!
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* Fluvoxamine slows the metabolism is an inhibitor of imipramine via CYP1A2 , CYP2C19 and CYP2D6CYP3A4 (moderate), which metabolize imipramine.
* {{theorSS}}
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