| start =
* Add lamotrigine according to the general dosing advice. Dose addjustment of carbamazepine is not necessary when lamotrigine is added.<ref name="freeman">{{Pubmed|9433333|Freeman et al. Mood stabilizer Combinations: A Review of Safety and Efficacy. Am J Psychiatry 1998;155:12-21}}</ref>
| cave =
* Abrupt stop of carbamazepine can cause serious lamotrigine rash as lamotrigine levels increase. <ref name="Koch"> {{Pubmed|12648898|Koch HJ et al. Clinically relevant reduction of lamotrigine concentrations by carbamazepine. J Clin Psychiatry 2005;66:400-1CombiCaLa}}</ref> * Carbamazepine likely speeds the metabolism of lamotrigine, but the clinical significance is unclear.<ref name="freeman"/><ref name="levyrh"> Levy RH et al, Metabolic Drug Interactions, Lippincott Williams & Wilkins, Philadelphia, 2000.</ref> * Lamotrigine may increase blood levels of carbamazepine metabolites, which can result in neurotoxicity (data about this are contradictory). <ref name="freeman" /><ref name="levyrh" /> * These two agents have less significant pharmacologic interactions than do lamotrigine and valproate <ref name="freeman"/>
}}