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* Risperidone is principally metabolized by CYP2D6 to an active metabolite.
* This There is no published data found about this combination of drugs . There may have possible synergistic effects. However, this combination will also have be additive side effects<ref name="freeman">{{Pubmed|9433333|Freeman et al. Mood stabilizer Combinations: A Review of Safety and Efficacy. Dose adaptation will be recommended for this combinationAm J Psychiatry 1998;155:12-21}}</ref>.
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* Start lithium according to the general dosing advice.