* '''Day 1-14:''' gradually Gradually decrease the dosage of hypericum. * '''Day 15:''' stop Stop administration of hypericum.

* '''Day 15-22:''' a A wash-out period of at least one week is necessary.<ref>{{Pubmed|18294328|Imai H, Kotegawa T, Tsutsumi K, Morimoto T, Eshima N, Nakano S, Ohashi K. The recovery time-course of CYP3A after induction by St John's wort administration. Br J Clin Pharmacol. 2008 May;65(5):701-7.}}</ref><ref>{{Pubmed|16640452|Wurglics M, Schubert-Zsilavecz M. Hypericum perforatum: a 'modern' herbal antidepressant: pharmacokinetics of active ingredients. Clin Pharmacokinet. 2006;45(5):449-68.}}</ref><ref>{{Pubmed|19593191|Derijks HJ, Janknegt R, Heerdink ER, De Koning FH, Krekels MM, Looij BJ, Egberts AC. Influence of antidepressant use on glycemic control in patients with diabetes mellitus: an open-label comparative study. J Clin Psychopharmacol. 2009 Aug;29(4):405-8.}}</ref><ref name="informatorium">{{KNMP|sertraline}}</ref>* '''Day 23:''' start Start sertraline 25-50 mg/day.| caveat = * Occurrence of the serotonin syndrome is possible without wash''' After day 44:''' If necessary increase dosage gradually to 50-out period.{{Lit-SSRI-Hypericum}} {{Lit-SSRI-Hypericum2}}200 mg/day