* '''Note''': 1. The safest way to switch to a long acting formulation, is first to first switch to an oral formulation of the drug. If and after reaching a patient develops an adverse effect/allergic reactions steady state switch to the drug, this effect will persist for a relatively long time if given a long acting formulationdepot.  2. On the other hand, the low adherence of With a patient might be direct switch to a reason not depot it is advisable to switch administer a low testdose in order to an oral formulationexclude adverse reactions.