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A wash-out period of one week is necessary.
* '''Day 1:''' simultaneously start administration of dosulepine in a low dosage of 25-50 mg/day.
* '''Day 8:''' stop administration of duloxetine and increase the dosage of dosulepine to 50-75 mg/day.
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* Duloxetine slows the metabolism of dosulepine by CYP2D6.
* Caution is necessary at the start of administration of dosulepine. }}