[[File{{Drugswitch | from = vortioxetine | to = paroxetine| stop = * '''Day 1:Empty''' reduce dosage of vortioxetine to 5 mg/day.jpg]]* '''Day 7:''' stop administration of vortioxetine.| start = * A wash-out period is not necessary, but care is needed.* '''Day 8:''' start administration of paroxetine in a normal dosage of 10-20 mg/day.| info = * Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.* Paroxetine is a strong inhibitor of CYP2D6, which metabolizes vortioxetine. }}