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* '''Day 8:''' start administration of duloxetine in a normal dosage of 30-60 mg/day.
* '''Day 15:''' increase the dosage of duloxetine if needed.
| info = * Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.<ref>[[European Medicines Agency]] | SmPC Brintellix 5 mg. </ref>* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.* Duloxetine is a inhibitor of CYP2D6, which metabolizes vortioxetine.<ref>[[European Medicines Agency]] | SmPC Brintellix 5 mg. </ref>}}