[[File:Empty{{Drugswitch | from = bupropion| to = vortioxetine | stop = * Gradually reduce dosage of bupropion to a maximum of 150 mg/ day.jpg]]* When a dosage of 150 mg/day is reached, stop administration.| start = * A wash-out period is not necessary.* Start administration of vortioxetine the next day in a dosage of 10 mg/day.| info = * Bupropion and its metabolites have long elimination times, so plasma concentrations will reduce gradually.}}