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{{Drugswitch
| from = Doxepine doxepine
| to = vortioxetine
| stop =
* '''Before day 1:''' gradually reduce dosage of doxepin to a maximum of 100 mg/day.
* '''Day 1:''' reduce dosage of doxepin doxepine to 50 mg/day.* '''Day 3:''' reduce dosage of doxepin doxepine to 25 mg/day.
* '''Day 8:''' stop administration of doxepin.
| start =
* A wash-out period is not necessary.* Start '''Day 8:''' start administration of vortioxetine the next day in a normal dosage of 10 mg/day.* '''Day 15:''' if necessary, increase dosage of sertraline.
| info =
* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
}}