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* '''Day 8:''' stop administration of amitriptyline.
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* A wash-out period is not necessary.* Start '''Day 8:''' start administration of vortioxetine the next day in a normal dosage of 10 mg/day.* '''Day 15:''' if necessary, increase dosage of sertraline.
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* {{theorSS}}Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.}}