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* '''Day 15:''' stop administration of duloxetine.
| start =
* A wash-out period is not necessary, but care is needed.
* '''Day 15:''' Start administration of vortioxetine the next day in a dosage of 10 mg/day.
| info =
* Duloxetine is a strong inhibitor of CYP2D6, which metabolizes vortioxetine.
* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
}}