[[File{{Drugswitch | from = fluoxetine| to = vortioxetine | stop = * '''Before day 1:Empty''' gradually reduce dosage of escitalopram to a maximum of 10 mg/day, when this dosage is > 10 mg/day.jpg]]* '''Day 1:''' when a dosage of 10 mg/day is reached, stop administration| start = * A wash-out period is not necessary, but care is needed.* '''Day 1:''' Start administration of vortioxetine the next day in a dosage of 10 mg/day.| info =* Fluoxetine is a strong inhibitor of CYP2D6, which metabolizes vortioxetine. * Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.}}