[[File{{Drugswitch | from = imipramine| to = vortioxetine | stop = * '''Before day 1:Empty''' gradually reduce dosage of imipramine to a maximum of 75 mg/day.jpg]]* '''Day 1:''' reduce dosage of imipramine to 50 mg/day.* '''Day 1:''' reduce dosage of imipramine to 25 mg/day.* '''Day 8:''' stop administration of aimipramine.| start = * A wash-out period is not necessary.* '''Day 8:''' start administration of vortioxetine in a dosage of 10 mg/day.| info = * Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.}}