* '''Before day 0:''' gradually reduce dosage of bupropion to a maximum of 60 mg/day.

* '''Day 1:''' reduce the dosage of duloxetine to 30 mg/day.

* '''Day 1:''' simultaneously start administration of nortriptyline in a low dosage of 25 mg/day.

* '''Day 8:''' stop administration of duloxetine and increase the dosage of nortriptyline to 50 mg/day.