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| stop =
* '''Day 1:''' reduce dosage of vortioxetine to 5 mg/day.
* '''Day 78:''' stop administration of vortioxetine.
| start =
* A wash-out period of 1 week is not necessary, but care is neededbecause of CYP2D6-inhibition and serotonergic actions.* '''Day 815:''' Start sertraline the next day in a normal dosage of 50 mg/day.
| info =
* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
* Sertraline is a strong inhibitor of CYP2D6, which metabolizes vortioxetine. }}