* '''Day 1:''' simultaneously start administration of dosulepine in a low dosage of 50-75 mg/day.

* '''Day 8:''' stop administration of venlafaxine and continue administration of dosulepine.

* “Start low, go slow” is not required, but caution with this switch is necessary.

* Venlafaxine is a weak inhibitor of CYP2D6, which metabolizes dosulepine.}}