* Gradually decrease the dosage of tranylcypromine with 10-20 mg/week. * When a dosage of 10 mg/day is reached, stop administration.{{Dec25p3d}}
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* '''Day 1-14:''' a wash-out period of two weeks is necessary. * '''Day 15:''' start maprotiline after this period in a low dosage of 25 mg/day.{{Inc25p3d}}
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* Occurrence of the serotonin syndrome is possible without a wash-out period.* The wash-out period is necessary for the MAO enzymes to restore their function.{{reviewTcrestore}}