* '''Before day 1:''' gradually reduce dosage of mirtazapine to a maximum of 30 mg/day, when this dosage is > 30 mg/day. * '''Day 1:''' reduce dosage of mirtazapine to 15 mg/day.* '''Day 8:''' stop administration of mirtazapine.{{StopMirtazapine}}
| start =
* '''Day 1:''' simultaneously start administration of agomelatine in a dosage of 25 mg/day.