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Mirtazapine-hypericum

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* '''Before day 1:''' gradually reduce dosage of mirtazapine to a maximum of 30 mg/day, when this dosage is > 30 mg/day. * '''Day 1:''' reduce dosage of mirtazapine to 15 mg/day.* '''Day 8:''' stop administration of mirtazapine.{{StopMirtazapine}}

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* '''Day 8-14:''' a wash-out period of one week is necessary.

* '''Day 15:''' start administration of hypericum in a dosage of 300 mg three times a day (900 mg/day).

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* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.{{caveSS}}

* Hypericum slows the metabolism of mirtazapine via CYP3A4.

~~{{review}}~~

}}

Anoek

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