* '''Before day 1:''' Gradually reduce dosage of bupropion to a maximum of 150 mg/ day.* '''Day 1:''' Stop administration of bupropion{{stopBupropion}}| start = {{Inc25p3d2}} * '''Day 1-3:''' start Start administration of imipramine the next day in a low dosage of 25 mg/day.* '''Day 4:''' increase dosage of imipramine to 50 mg/day and continue slowly increasing the dosage depending on the condition of the patient.