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* '''Day 8-14:''' a wash-out period of one week is necessary.
* '''Day 15:''' start administration of agomelatine after this period in a dosage of 25 mg/day.
* If ''' Day 22: ''' if necessary, the dosage of agomelatine can be increased to 50 mg/day.
| info =
* Fluvoxamine stops the metabolism of agomelatine via CYP1A2 (90%) and via CYP2C9/2C19 (10%).<ref name="agoswitch"> {{Pubmed|20196187|McAllister-Williams RH et al. The use of antidepressants in clinical practice: focus on agomelatine. Hum Psychopharmacol. 2010 Mar 1;25(2):95-102}}</ref>
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