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Fluvoxamine-mirtazapine

211 bytes removed, 13:52, 21 October 2015
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| to = mirtazapine
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* '''Before day 1:''' gradually reduce dosage of fluvoxamine to a maximum of 50 mg/ day, when this dosage is > 50 mg/day. * '''Day 1:''' reduce fluvoxamine to a dosage of 25 mg/day. * '''Day 8:''' stop administration of fluvoxamine.{{stopFluvoxamine}}
| start =
* '''Day 89:''' start administration of mirtazapine in a low dosage of 15 mg/day for one week.* '''Day 1516:''' gradually increase dosage of mirtazapine to normal (30 mg/day)target dose.
| info =
* Caution with this switch is necessary, because fluvoxamine slows the metabolism of mirtazapine via CYP1A2, CYP2C9, CYP2D6 and CYP3A4. The inhibiting effect of fluvoxamine can continue up to two weeks after stopping administration.
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