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Fluoxetine-maprotiline

136 bytes removed, 13:53, 28 October 2015
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* Gradually reduce dosage of fluoxetine to a maximum of 20 mg/ day, when this dosage is > 20 mg/day. * When a dosage of 20 mg/day is reached, stop administration.{[stopFluoxetine}}
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Caution is necessary for at least four weeks.
* '''Day 12:''' start administration of maprotiline in a low dosage of 25 mg/day.* '''Day 1415:''' increase dosage of maprotiline to 50 mg/day.* '''Day 2829:''' gradually increase dosage of maprotiline to 75 mg/day and more.
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* Fluoxetine and norfluoxetine slow the metabolism of maprotiline via CYP2D6.
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* Start low, go slow for maprotiline.
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