* '''Before day 1:''' gradually reduce dosage of sertraline to a maximum of 50 mg/day when this dosage is > 50 mg/day. * '''Day 1:''' reduce dosage of sertraline to a maximum of 25 mg/day. {{stopSertraline}}
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Caution is necessary.
| info =
* Sertraline dose-dependently slows the metabolism of maprotiline via CYP2D6.