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Fluoxetine-clomipramine

230 bytes removed, 14:35, 28 October 2015

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* Gradually reduce dosage of fluoxetine to a maximum of 20 mg/ day, when this dosage is > 20 mg/day. * When a dosage of 20 mg/day is reached, stop administration{{stopFluoxetine1}}.

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Caution is necessary for at least four weeks.

* '''Day 12:''' start administration of clomipramine in a low dosage of 25 mg/day.* '''Day 89:''' increase dosage of clomipramine to 50 mg/day.* '''Day 2829:''' gradually increase dosage of clomipramine to 75 mg/day and more.

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* Fluoxetine and norfluoxetine slow the metabolism of clomipramine via CYP2D6.

* Norfluoxetine has a halflife of at least 1 week: it takes therefore 1 month for elemination.{{longt1/2fluvox}}

* Start low, go slow for clomipramine.

~~{{review}}~~

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Anoek

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Fluoxetine-clomipramine

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