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Amitriptyline-duloxetine

300 bytes removed, 13:01, 2 November 2015

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* '''Day 0:''' gradually reduce dosage of amitriptyline to a maximum of 50-100 mg/day, when this dosage is > 100 mg/day.* '''Day 1-7:''' reduce dosage of amitriptyline to 25-50 mg/day.* '''Day 8:''' stop administration of amitriptyline. {{stopAmitriptyline1}}

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* '''Day 89-1415:''' a wash-out period of one week is necessary.* '''Day 1516:''' start administration of duloxetine in a normal dosage of 60 mg/day.

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* ~~Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.~~{{theorSS}}

* Duloxetine is an inhibitor of CYP2D6, which metabolizes amitriptyline.

~~{{review}}~~

}}

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Amitriptyline-duloxetine

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