* '''Before day 1:''' gradually reduce dosage of maprotiline to a maximum of 75 mg/day.* '''Day 1:''' reduce dosage of maprotiline to 50 mg/day.* '''Day 8:''' reduce dosage of maprotiline to 25 mg/day.* '''Day 15:''' stop dosage of maprotiline.{{stopMaprotiline}}
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* A No wash-out period is not necessaryneeded.* '''Day 15:''' start administration of vortioxetine in a dosage of 10 mg/day. |info ={{review}}