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Clomipramine-fluvoxamine

254 bytes removed, 12:00, 4 November 2015
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* '''Before day 1:''' gradually reduce dosage of clomipramine to a maximum of 50 mg/day.* '''Day 1:''' reduce dosage of clomipramine to 25 mg/day.* '''Day 8:''' stop dosage of clomipramine.{{stopClomipramine}}
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* '''Day 89:''' start administration of fluvoxamine in a normal dosage of 50 mg/day.* '''Day 1516:''' increase dosage of fluvoxamine.
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* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.{{theorSS}}
* Fluvoxamine is an inhibitor of CYP1A2, CYP2C19 and CYP3A4 (moderate), which metabolize clomipramine.
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