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Duloxetine-maprotiline

191 bytes removed, 12:25, 4 November 2015
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* '''Before day 1:''' gradually reduce dosage of duloxetine to a maximum of 60 mg/day. * '''Day 1:''' reduce the dosage of duloxetine to 30 mg/day.* '''Day 8:''' stop administration of duloxetine.{{stopDuloxetine}}
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No wash-out period is needed.
* '''Day 89:''' start administration of maprotiline in a low dosage of 25 mg/day.* '''Day 1516:''' increase the dosage of maprotiline to 50 mg/day.
| info =
* Duloxetine slows the metabolism of maprotiline by CYP2D6.
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