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Trazodone-duloxetine

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* '''Before day 1:''' gradually reduce dosage of trazodone to a maximum of 100-150 mg/day, when this dosage is > 200 mg/day. * '''Day 1:''' reduce dosage of trazodone to 75 mg or maintain on 100 mg/day.* '''Day 8:''' stop administration of trazodone.{{stopTrazodone}}

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* A wash-out period is not necessary, but care is needed.

* '''Day 89:''' start administration of duloxetine in a normal dosage of 60 mg/day.

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* ~~Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.~~{{theorSS}}

* Duloxetine is a strong inhibitor of CYP2D6, which metabolizes trazodone.

* The content of trazodone in the tablet, for example 100 mg or 150 mg, determines which exact doses are given.{{~~review~~trazoTablet}} }}

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Trazodone-duloxetine

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