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* No wash-out period is needed. <ref name="vortiswitch"> {{Pubmed|24570588 |Katona et al. New generation multi-modal antidepressants: focus on vortioxetine for major depressive disorder. 2014 2014 Feb 19;10:349-54}}</ref> <ref name="informatorium">{{KNMP|vortioxetine}}</ref>
* '''Day 9:''' start trazodone in a dosage of 100-150 mg/day.
* If necessary, increase the dosage of trazodone gradually to a maximum of 400 mg/day.