* Plasma monitoring for TCA's is advisable, because of plasma-reponse relations, genetic polymorphism and under/overdosing.<ref >https{{cite web | url =http://tdm-monografie.org/monografie/tca-tricyclische-antidepressiva monografie antidepressiva bloedspiegelbepalingen(|language =Dutch)| publisher =NVZA access-date =16 June 2016}}</ref>