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* Gradually reduce dosage of sertraline to a maximum of 50 mg/ day, when this dosage is > 50 mg/day.
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* '''Day 1:''' reduce sertraline to a dosage of 25 mg/day and start administration of mianserine in a normal dosage of 15-30 mg/day for one week.
* '''Day 8:''' stop administration of sertraline and continue administration of just mianserine. }}