| stop = * '''Before day 1:''' gradually reduce dosage of sertraline to a maximum of 50 mg/day, when this dosage is > 50 mg/day. * '''Day 1:''' when a dosage of 50 mg/day is reached{{StopSSRI, stop administrationSNRI}}| start = {{StartAntidepressant}}* A wash-out period is not necessary.| info =* '''Day 1:''' start administration of Safe target dose vortioxetine in a dosage of = 10 mg/day.| info = * Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.{{theorSS}}