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* '''Day 1:''' Start with the target dose
* '''Day 9 and after:''' Gradually increase dose as necessary<ref name="informatorium">{{KNMP|tranylcypromine}}</ref> <ref>Dr. M.J.Blom et al. (2009) Gebruik van klassieke MAO-remmers</ref>
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* Tranylcypromine has to be phased out to avoid withdrawal symptoms.