{{Inc25p3d}}* Start administration of '''Day 1:''' start nortriptyline in a low dosage of 25 mg/day. * '''Day 8:''' increase nortriptyline to a dosage of 50 mg/day.
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* Bupropion slows the metabolism of nortriptyline via CYP2D6.
* Caution is necessary at the start of administration of nortriptyline.