Switch medication from Zuclopenthixol LA to Penfluridol.[1]
[2]
Stop Zuclopenthixol LA
- Day 1: Last depot injection
Start Penfluridol
- Week 3: start with 10 mg
- Week 4: increase dose to 20 mg
- Week 5 and further: adjust dose according to clinical presentation
More information
- During this switch you could monitor ECG, especially in patients prone to QT-conduction problems.
- There is a possibility of QT interval prolongation.[3]
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
- ↑ Stöllberger C, Huber JO, Finsterer J, Antipsychotic drugs and QT prolongation. Int Clin Psychopharmacol. 2005 Sep;20(5):243-51.
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Stop Zuclopenthixol LA 
Start Penfluridol
More information