Paroxetine-imipramine
From Psychiatrienet
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Switch medication from paroxetine to imipramine.[1] [2]
Stop paroxetine - Day 0: gradually reduce dosage of paroxetine to a maximum of 20 mg/day when this dosage is > 20 mg/day.
- Day 1: reduce dosage of paroxetine to a maximum of 10 mg/day.
- Day 8: stop dosage of paroxetine.
Start imipramineCaution is necessary.
- Day 8: start administration of imipramine in a low dosage of 25 mg/day.
- Day 15: increase administration of imipramine to a dosage of 75 mg/day.
More information- Paroxetine slows the metabolism of imipramine via CYP1A2 and CYP2D6.
- Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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