Combining-Topiramate-Risperidone

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Topiramate
Type moodstabilizer
Group anticonvulsant
links
ATC-code N03AX11
PubChem 5284627
PubMed Topiramate
Drugs.com topiramate
Kompas (Dutch) Topiramate
Wikipedia Topiramate
Risperidone
Type antipsychotic
Group atypical AP
Other use moodstabilizer
links
ATC-code N05AX08
Medscape Risperidone
PubChem 5073
PubMed Risperidone
Drugs.com risperidone
Kompas (Dutch) Risperidone
Wikipedia Risperidone

Adding risperidone to topiramate.

Infobord.png General information
  • Topiramate induces CYP3A4 and is an inhibitor of CYP2C19.
  • Risperidone is principally metabolized by CYP2D6 to an active metabolite 9-OH-risperidone (paliperidone).
  • Topiramate induces CYP3A4 and is an inhibitor of CYP2C19.
  • Risperidone is principally metabolized by CYP2D6 to an active metabolite.
  • This combination of drugs may have possible synergistic effects. However, this combination will also have additive side effects. Dose adaptation will be recommended for this combination.
Eenrichtingbord.png Start risperidone
  • Start risperidone according general dosing advice.
Letopbord.png Cave
  • Caution is advised when topiramate is prescribed with other drugs that predispose patients to heat-related disorders, including carbonic anhydrase inhibitors and drugs with anticholinergic activity. [5]


  1. ↑ 1.0 1.1 Farmacotherapeutisch Kompas - topiramaat (dutch)
  2. ↑ 2.0 2.1 KNMP; Informatorium Medicamentorum 2023; Monografie "risperidon" (Dutch)
  3. ↑ Woods SW; Chlorpromazine equivalent doses for the newer atypical antipsychotics J Clin Psychiatry 2003;64:663-667
  4. ↑ 4.0 4.1 The Lundbeck Institute; Psychotropics; Terminal Plasma Half-lives
  5. ↑ Drugs.com risperidone
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